Pathomechanisms of Prenatally Programmed Adult Diseases
نویسندگان
چکیده
Based on epidemiological observations Barker et al. put forward the hypothesis/concept that an adverse intrauterine environment (involving insufficient nutrient supply, chronic hypoxia, stress, and toxic substances) is important risk factor for development of diseases later in life. The fetus responds to unfavorable with adaptive reactions, which ensure survival short run, but at expense initiating pathological processes leading adult diseases. In this review, major mechanisms (including telomere dysfunction, epigenetic modifications, cardiovascular–renal–endocrine–metabolic reactions) will be outlined, a particular emphasis role oxidative stress fetal origin
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ژورنال
عنوان ژورنال: Antioxidants
سال: 2023
ISSN: ['2076-3921']
DOI: https://doi.org/10.3390/antiox12071354